Transition-metal/Lewis acid free synthesis of acyl benzothiophenes via C-C bond forming reaction
نویسندگان
چکیده
A simple and single-step synthesis of 2- and 3-acyl substituted benzothiophenes has been described via environmentally benign acylation of benzothiophene with in situ generated acyl trifluoroacetates. Both aliphatic and aromatic carboxylic acids participated in trifluoroacetic anhydride/phosphoric acid mediated C-C bond forming reactions under solvent-free conditions affording acyl benzothiophenes in good overall yields.
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ورودعنوان ژورنال:
- Beilstein Journal of Organic Chemistry
دوره 3 شماره
صفحات -
تاریخ انتشار 2007